Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sh3gl1tm1Pdc
Name:	SH3-domain GRB2-like 1; targeted mutation 1, Pietro De Camilli
MGI ID:	MGI:5468725
Synonyms:	Endo-A2 null
Gene:	Sh3gl1  Location: Chr17:56323750-56343635 bp, - strand  Genetic Position: Chr17, 29.11 cM
Alliance:	Sh3gl1tm1Pdc page

Germline Transmission:	Earliest citation of germline transmission: J:178947
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All coding exons following exon 1 (exons 2-10) were replaced with a neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:178947)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh3gl1 Mutation:	37 strains or lines available

Original:	J:178947 Milosevic I, et al., Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron. 2011 Nov 17;72(4):587-601
All:	8 reference(s)