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Chrm5tm1.1Anis
Targeted Allele Detail
Summary
Symbol: Chrm5tm1.1Anis
Name: cholinergic receptor, muscarinic 5; targeted mutation 1.1, Akinori Nishi
MGI ID: MGI:5466563
Gene: Chrm5  Location: Chr2:112309516-112311114 bp, - strand  Genetic Position: Chr2, 57.02 cM
Alliance: Chrm5tm1.1Anis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192760
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of the open reading frame and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the open reading frame. Cre-mediated recombination removed the open reading frame and the neo cassette. (J:192760)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm5 Mutation:  40 strains or lines available
References
Original:  J:192760 Kuroiwa M, et al., Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons. Neuropharmacology. 2012 Dec;63(7):1248-57
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory