Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mefvtm1Bhk
Name:	Mediterranean fever; targeted mutation 1, Beverly H Koller
MGI ID:	MGI:5465109
Gene:	Mefv  Location: Chr16:3525082-3535961 bp, - strand  Genetic Position: Chr16, 2.18 cM
Alliance:	Mefvtm1Bhk page

Germline Transmission:	Earliest citation of germline transmission: J:192443
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace entire coding region with a neomycin resistance (neo) cassette in reverse orientation to the gene. Northern blot analysis confirmed the absence of transcript expression in elicited peritoneal neutrophils. (J:192443)

Generation of the Mefvtm1Bhk allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mefv Mutation:	44 strains or lines available

Original:	J:192443 Hesker PR, et al., Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1beta levels. PLoS One. 2012;7(11):e51105
All:	2 reference(s)