Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Optctm1.1Pnb
Name:	opticin; targeted mutation 1.1, Paul N Bishop
MGI ID:	MGI:5462239
Gene:	Optc  Location: Chr1:133824937-133835737 bp, - strand  Genetic Position: Chr1, 58.02 cM
Alliance:	Optctm1.1Pnb page

Germline Transmission:	Earliest citation of germline transmission: J:191528
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 through part of exon 4 was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in the eye. (J:191528)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Optc Mutation:	43 strains or lines available

Original:	J:191528 Le Goff MM, et al., The vitreous glycoprotein opticin inhibits preretinal neovascularization. Invest Ophthalmol Vis Sci. 2012 Jan;53(1):228-34
All:	3 reference(s)