Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptch1tm1.1Hahn
Name:	patched 1; targeted mutation 1.1, Heidi Hahn
MGI ID:	MGI:5447563
Synonyms:	Ptchdel
Gene:	Ptch1  Location: Chr13:63656142-63721274 bp, - strand  Genetic Position: Chr13, 32.8 cM
Alliance:	Ptch1tm1.1Hahn page

Germline Transmission:	Earliest citation of germline transmission: J:149148
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted into intron 7 and a second loxP site followed by a frt-flanked neo cassette was inserted into intron 9. Cre-mediated recombination remvoed exons 8 and 9. (J:149148)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptch1tm1.1Hahn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptch1 Mutation:	115 strains or lines available

Original:	J:149148 Zibat A, et al., Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts. Carcinogenesis. 2009 Jun;30(6):918-26
All:	3 reference(s)