Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tpcn2tm1.1Dren
Name:	two pore segment channel 2; targeted mutation 1.1, Dejian Ren
MGI ID:	MGI:5446047
Gene:	Tpcn2  Location: Chr7:144740261-144837748 bp, - strand  Genetic Position: Chr7, 89.02 cM
Alliance:	Tpcn2tm1.1Dren page

Germline Transmission:	Earliest citation of germline transmission: J:189070
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The exon containing the translation start site was flanked by loxP sites via homologous recombination. Cre mediated recombination removed the loxP-flanked sequence. (J:189070)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpcn2 Mutation:	50 strains or lines available

Original:	J:189070 Wang X, et al., TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes. Cell. 2012 Oct 12;151(2):372-83
All:	5 reference(s)