Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tpcn1tm1.1Dren
Name:	two pore channel 1; targeted mutation 1.1, Dejian Ren
MGI ID:	MGI:5446045
Gene:	Tpcn1  Location: Chr5:120672222-120726731 bp, - strand  Genetic Position: Chr5, 60.63 cM
Alliance:	Tpcn1tm1.1Dren page

Germline Transmission:	Earliest citation of germline transmission: J:189070
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The exon containing the translation start site was floxed via homologous recombination. Cre mediated recombination removed the foxed sequence. (J:189070)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpcn1 Mutation:	69 strains or lines available

Original:	J:189070 Wang X, et al., TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes. Cell. 2012 Oct 12;151(2):372-83
All:	4 reference(s)