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Grntm1.1Geno
Targeted Allele Detail
Summary
Symbol: Grntm1.1Geno
Name: granulin; targeted mutation 1.1, Genoway
MGI ID: MGI:5443906
Gene: Grn  Location: Chr11:102321333-102327635 bp, + strand  Genetic Position: Chr11, 66.29 cM
Alliance: Grntm1.1Geno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188420
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 4 via homologous recombination. Cre mediated recombination deleted exons 2 - 4. qRT-PCR and immunoblot analysis confirmed the absence of full length RNA and protein expression in the brains from homozygous mice. (J:188420)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grn Mutation:  44 strains or lines available
References
Original:  J:188420 Wils H, et al., Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice. J Pathol. 2012 Sep;228(1):67-76
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory