Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Map3k12tm1.2Adia
Name:	mitogen-activated protein kinase kinase kinase 12; targeted mutation 1.2, Aaron DiAntonio
MGI ID:	MGI:5440724
Gene:	Map3k12  Location: Chr15:102406079-102425311 bp, - strand  Genetic Position: Chr15, 57.63 cM, cytoband F3
Alliance:	Map3k12tm1.2Adia page

Germline Transmission:	Earliest citation of germline transmission: J:188476
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination ore Map3k12tm1.1Adia removes exons 8 through 11. Western blot analysis confirmed the absence of protein expression in the brain. (J:188476)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k12 Mutation:	39 strains or lines available

Original:	J:188476 Miller BR, et al., A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci. 2009 Apr;12(4):387-9
All:	5 reference(s)