Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ngbtm1.2Geno
Name:	neuroglobin; targeted mutation 1.2, Genoway
MGI ID:	MGI:5440446
Gene:	Ngb  Location: Chr12:87144305-87149313 bp, - strand  Genetic Position: Chr12, 41.29 cM, cytoband D3
Alliance:	Ngbtm1.2Geno page

Germline Transmission:	Earliest citation of germline transmission: J:188398
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstrea of exon 2 and an FRT flanked neo cassette and loxP site were introduced downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed exons 2 and 3 and the neo cassette. RT-QPCR, IHC and western blot analyses confirmed the absence of mRNA and protein expression in homozygous mice. (J:187107, J:188398)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ngb Mutation:	9 strains or lines available

Original:	J:188398 Hundahl CA, et al., Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo. PLoS One. 2011;6(12):e28160
All:	7 reference(s)