Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mcm8tm1.1Geno
Name:	minichromosome maintenance 8 homologous recombination repair factor; targeted mutation 1.1, Genoway
MGI ID:	MGI:5439837
Gene:	Mcm8  Location: Chr2:132658061-132686117 bp, + strand  Genetic Position: Chr2, 64.75 cM, cytoband F3
Alliance:	Mcm8tm1.1Geno page

Germline Transmission:	Earliest citation of germline transmission: J:187623
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT_flanked neo cassette with a 5' loxP site was inserted upstream of exon 11. An additional loxP site was inserted downstream of exon 12. Cre-mediated recombination removed the neo cassette, exon 11 and exon 12. Western blot analysis confirmed the absence of protein expression in testis. (J:187623)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcm8 Mutation:	37 strains or lines available

Original:	J:187623 Lutzmann M, et al., MCM8- and MCM9-Deficient Mice Reveal Gametogenesis Defects and Genome Instability Due to Impaired Homologous Recombination. Mol Cell. 2012 Aug 24;47(4):523-34
All:	3 reference(s)