Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kpna1tm1.2Yyo
Name:	karyopherin subunit alpha 1; targeted mutation 1.2, Yoshihiro Yoneda
MGI ID:	MGI:5439493
Synonyms:	Impalpha5-
Gene:	Kpna1  Location: Chr16:35803693-35859479 bp, + strand  Genetic Position: Chr16, 25.43 cM, cytoband B4-B5
Alliance:	Kpna1tm1.2Yyo page

Germline Transmission:	Earliest citation of germline transmission: J:188099
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Flp-mediated recombination of Kpna1tm1Yyo removed exons 2 and 3. Western blot analysis confirmed the absence of protein expression in the brain, thymus, lung, heart, kidney, liver, spleen, testis and ovary. (J:188099)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kpna1 Mutation:	67 strains or lines available

Original:	J:188099 Moriyama T, et al., Targeted disruption of one of the importin alpha family members leads to female functional incompetence in delivery. FEBS J. 2011 May;278(9):1561-72
All:	2 reference(s)