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Spaca1tm1.1Osb
Targeted Allele Detail
Summary
Symbol: Spaca1tm1.1Osb
Name: sperm acrosome associated 1; targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University
MGI ID: MGI:5439282
Gene: Spaca1  Location: Chr4:34024872-34050067 bp, - strand  Genetic Position: Chr4, 16.63 cM, cytoband A5
Alliance: Spaca1tm1.1Osb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187685
Parent Cell Line:  EGR-G01 (ES Cell)
Strain of Origin:  (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and inverted FRT flanked neo cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 3 and 4. (J:187685)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spaca1 Mutation:  16 strains or lines available
Notes
EGR-G01 cells carry one copy of Tg(CAG-EGFP,Acr-EGFP)2Osb.
References
Original:  J:187685 Fujihara Y, et al., SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Development. 2012 Oct;139(19):3583-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory