Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Shank3tm1.1Geno
Name:	SH3 and multiple ankyrin repeat domains 3; targeted mutation 1.1, Genoway
MGI ID:	MGI:5435700
Synonyms:	Shank3alphabeta-, SHANK3delta11-
Gene:	Shank3  Location: Chr15:89383826-89444464 bp, + strand  Genetic Position: Chr15, 44.96 cM
Alliance:	Shank3tm1.1Geno page

Germline Transmission:	Earliest citation of germline transmission: J:186719
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 11 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 11 via homologous recombination. Recombinase mediated recombination deleted exon 11 and the neo cassette. (J:186719)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shank3 Mutation:	77 strains or lines available

Original:	J:186719 Schmeisser MJ, et al., Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 2012 Jun 14;486(7402):256-60
All:	19 reference(s)