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Litaftm1.1Ics
Targeted Allele Detail
Summary
Symbol: Litaftm1.1Ics
Name: LPS-induced TN factor; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:5433218
Gene: Litaf  Location: Chr16:10777137-10810985 bp, - strand  Genetic Position: Chr16, 6.28 cM, cytoband B1-B3
Alliance: Litaftm1.1Ics page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186411
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed the floxed exon 2. Western blot analysis confirmed the absence of protein expression in nerves. (J:186411)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Litaf Mutation:  13 strains or lines available
References
Original:  J:186411 Somandin C, et al., LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: Implications for Charcot-Marie-Tooth disease. Glia. 2012 Oct;60(10):1518-28
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory