Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hspb8tm1.1Depr
Name:	heat shock protein 8; targeted mutation 1.1, Christophe Depre
MGI ID:	MGI:5433119
Gene:	Hspb8  Location: Chr5:116546550-116560923 bp, - strand  Genetic Position: Chr5, 56.41 cM
Alliance:	Hspb8tm1.1Depr page

Germline Transmission:	Earliest citation of germline transmission: J:186292
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted immediately downstream. Properly targeted mice were crossed to cre expressing mice to excise the floxed selection cassette and exon 1. (J:186292)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspb8 Mutation:	17 strains or lines available

Original:	J:186292 Qiu H, et al., H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload. Circulation. 2011 Jul 26;124(4):406-15
All:	1 reference(s)