Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nxnl1tm1.2Tlev
Name:	nucleoredoxin-like 1; targeted mutation 1.2, Thierry Leveillard
MGI ID:	MGI:5432155
Gene:	Nxnl1  Location: Chr8:72013199-72019245 bp, - strand  Genetic Position: Chr8, 34.43 cM
Alliance:	Nxnl1tm1.2Tlev page

Germline Transmission:	Earliest citation of germline transmission: J:186370
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	BALB/c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1. An FRT flanked neo cassette with a 5' losP site was inserted downstream of exon 1. FLP mediated recombination removed the neo cassette. Cre mediated recombination removed exon 1. Western blot analysis confirmed the abscence of protein expression in the retina. (J:186370)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nxnl1 Mutation:	11 strains or lines available

Original:	J:186370 Cronin T, et al., The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress. Cell Death Differ. 2010 Jul;17(7):1199-210
All:	3 reference(s)