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Leprtm1Jke
Targeted Allele Detail
Summary
Symbol: Leprtm1Jke
Name: leptin receptor; targeted mutation 1, Joel K Elmquist
MGI ID: MGI:5426228
Synonyms: LeprloxTB
Gene: Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Alliance: Leprtm1Jke page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184572
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A floxed transcription blocker was inserted into intron 16. (J:184572)
Generation of the Leprtm1Jke allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  121 strains or lines available
References
Original:  J:184572 Berglund ED, et al., Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J Clin Invest. 2012 Mar 1;122(3):1000-9
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory