Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: A4gnttm1Jnaka Name: alpha-1,4-N-acetylglucosaminyltransferase; targeted mutation 1, Jun Nakayama MGI ID: MGI:5425954 Gene: A4gnt  Location: Chr9:99494555-99504420 bp, + strand  Genetic Position: Chr9, 51.91 cM Alliance: A4gnttm1Jnaka page

Hyperplasia, dysplasia and adenocarcinoma in A4gnttm1Jnaka/A4gnttm1Jnaka pyloric mucosa Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:184485
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neo cassette replaced the exon 2 and the coding sequence in exon 3. Immunohistochemistry confirmed the absence of protein expression in stomach and duodenum. (J:184485)

Generation of the A4gnttm1Jnaka allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

List all tumor models in MMHCdb carrying A4gnttm1Jnaka

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any A4gnt Mutation:	16 strains or lines available

Original:	J:184485 Karasawa F, et al., Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest. 2012 Mar 1;122(3):923-34
All:	1 reference(s)