Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tesctm1Itl
Name:	tescalcin; targeted mutation 1, inGenious Targeting Laboratory
MGI ID:	MGI:5316034
Gene:	Tesc  Location: Chr5:118165808-118199943 bp, + strand  Genetic Position: Chr5, 57.84 cM, cytoband F
Alliance:	Tesctm1Itl page

Germline Transmission:	Earliest citation of germline transmission: J:182299
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	(C57BL/6NTac x 129S6/SvEvTac)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4, 5, and 6 were replaced by a neomycin resistance gene in reverse orientation. RT-PCR confirmed the absence of normal transcript. A low level of truncsted transcript lacking exon 3 in addition to exons 4, 5, and 6 was detected. Western blot analysis confirmed the absence of protein in brain, heart, and platelets. (J:182299)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tesc Mutation:	35 strains or lines available

Original:	J:182299 Ukarapong S, et al., Megakaryocyte development is normal in mice with targeted disruption of Tescalcin. Exp Cell Res. 2012 Mar 10;318(5):662-9
All:	1 reference(s)