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Bst2tm1.1Bsz
Targeted Allele Detail
Summary
Symbol: Bst2tm1.1Bsz
Name: bone marrow stromal cell antigen 2; targeted mutation 1.1, Paul Bieniasz
MGI ID: MGI:5308812
Gene: Bst2  Location: Chr8:71986899-71990100 bp, - strand  Genetic Position: Chr8, 34.43 cM
Alliance: Bst2tm1.1Bsz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180252
Parent Cell Line:  CY2.4 (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into exon 1. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed most of exon 1. RT-PCR confirmed the absence of transcript expression in mouse embryonic fibroblasts. (J:180252)
Generation of the Bst2tm1Bsz and Bst2tm1.1Bsz alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bst2 Mutation:  12 strains or lines available
References
Original:  J:180252 Liberatore RA, et al., Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18097-101
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory