Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lair1tm1.1Jco
Name:	leukocyte-associated Ig-like receptor 1; targeted mutation 1.1, John E Coligan
MGI ID:	MGI:5308465
Gene:	Lair1  Location: Chr7:4006401-4066178 bp, - strand  Genetic Position: Chr7, 2.31 cM
Alliance:	Lair1tm1.1Jco page

Germline Transmission:	Earliest citation of germline transmission: J:180203
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 4 followed by a frt-flanked neomycin resistance (neo) cassette and a second loxP site inserted downstream of exon 8 via homologous recombination. Cre-mediated recombination removed exons 4-8 and the neo cassette. Flow cytometric analysis confirmed that LAIR1 could not be detected on T, B, and NK cells derived from splenocytes. (J:180203)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lair1 Mutation:	35 strains or lines available

Original:	J:180203 Tang X, et al., Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype. J Immunol. 2012 Jan 15;188(2):548-58
All:	6 reference(s)