Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slco1c1tm1.1Arte
Name:	solute carrier organic anion transporter family, member 1c1; targeted mutation 1.1, TaconicArtemis
MGI ID:	MGI:5308446
Synonyms:	Oatp1c1 delta
Gene:	Slco1c1  Location: Chr6:141470094-141515903 bp, + strand  Genetic Position: Chr6, 72.38 cM, cytoband G1
Alliance:	Slco1c1tm1.1Arte page

Germline Transmission:	Earliest citation of germline transmission: J:180950
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was flanked with loxP sites. Deletion of exon 3 by cre excision caused loss of function by removing part of the organic anion transporter domain and generating a frameshift from exon 2 to exon 4-11 followed by a premature stop at codon 52. PCR analysis confirmed the removal of exon 3 in mRNA. (J:180950)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slco1c1 Mutation:	33 strains or lines available

Original:	J:180950 Mayerl S, et al., Impact of oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain. Endocrinology. 2012 Mar;153(3):1528-37
All:	9 reference(s)