Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igf1rtm2.1Arge
Name:	insulin-like growth factor I receptor; targeted mutation 2.1, Argiris Efstratiadis
MGI ID:	MGI:5306047
Gene:	Igf1r  Location: Chr7:67602575-67883416 bp, + strand  Genetic Position: Chr7, 37.27 cM
Alliance:	Igf1rtm2.1Arge page

Germline Transmission:	Earliest citation of germline transmission: J:178908
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was flanked by a floxed neo cassette in intron 2 and a single loxP site in intron 3. Subsequently, properly targeted mice were crossed to cre expressing mis leading to germ line excision of exon 3. (J:60711)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1r Mutation:	86 strains or lines available

Original:	J:178908 Okano T, et al., Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. J Neurosci. 2011 Dec 7;31(49):18104-18
All:	3 reference(s)