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Tdrd7tm1.1Chum
Targeted Allele Detail
Summary
Symbol: Tdrd7tm1.1Chum
Name: tudor domain containing 7; targeted mutation 1.1, Shinichiro Chuma
MGI ID: MGI:5305937
Gene: Tdrd7  Location: Chr4:45965334-46034761 bp, + strand  Genetic Position: Chr4, 24.48 cM
Alliance: Tdrd7tm1.1Chum page
Haploid spermatid defect in Tdrd7tm1.1Chum/Tdrd7tm1.1Chum mice

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173550
Parent Cell Line:  KY1.1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsOne loxP site was inserted upstream of exon 8 and an FRT flanked PGK-neomycin selection cassette together with a second loxP site was inserted downstream of exon 12. Exons 8-12 were subsequently removed by cre excision. (J:173550)
Generation of the Tdrd7tm1.1Chum allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tdrd7 Mutation:  43 strains or lines available
References
Original:  J:173550 Tanaka T, et al., Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10579-84
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory