Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sting1tm1Camb
Name:	stimulator of interferon response cGAMP interactor 1; targeted mutation 1, John C Cambier
MGI ID:	MGI:5301711
Synonyms:	MPYS-, Tmem173-
Gene:	Sting1  Location: Chr18:35866732-35873607 bp, - strand  Genetic Position: Chr18, 19.23 cM, cytoband B3
Alliance:	Sting1tm1Camb page

Germline Transmission:	Earliest citation of germline transmission: J:179270
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: An Frt flanked neo cassette followed by a loxP site was inserted intron 5. A second loxP site was inserted in intron 2. Western blot analysis of splenocyte proteins and intracellular staining of peripheral blood confirmed the absence of protein product. Absence of transcript was confirmed by RT-PCR. (J:179270)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sting1 Mutation:	49 strains or lines available

Original:	J:179270 Jin L, et al., MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 1;187(5):2595-601
All:	20 reference(s)