Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Oxsr1tm1.2Ssy
Name:	oxidative-stress responsive 1; targeted mutation 1.2, Sung-Sen Yeh
MGI ID:	MGI:5297492
Synonyms:	OSR1-
Gene:	Oxsr1  Location: Chr9:119067498-119151493 bp, - strand  Genetic Position: Chr9, 71.33 cM
Alliance:	Oxsr1tm1.2Ssy page

Germline Transmission:	Earliest citation of germline transmission: J:177443
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 9 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 10 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exons 9 and 10. (J:177443)

Generation of the Oxsr1tm1.1Ssy and Oxsr1tm1.2Ssy alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oxsr1 Mutation:	41 strains or lines available

Original:	J:177443 Lin SH, et al., Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43
All:	4 reference(s)