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Epb41l3tm1.1Jglt
Targeted Allele Detail
Summary
Symbol: Epb41l3tm1.1Jglt
Name: erythrocyte membrane protein band 4.1 like 3; targeted mutation 1.1, Jean-Antoine Girault
MGI ID: MGI:5297225
Synonyms: protein 4.1BKO3
Gene: Epb41l3  Location: Chr17:69382678-69596984 bp, + strand  Genetic Position: Chr17, 40.15 cM
Alliance: Epb41l3tm1.1Jglt page
Limb clasping and gait abnormalities in Epb41l3tm1.1Jglt/Epb41l3tm1.1Jglt mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177866
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3. A floxed hygro-GFP cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the hygro-GFP cassette. The absence of protein expression was confirmed by western blot analysis on brain and sciatic nerve extract. (J:177866)
Generation of the Epb41l3tm1.1Jglt allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epb41l3 Mutation:  46 strains or lines available
References
Original:  J:177866 Cifuentes-Diaz C, et al., Protein 4.1B contributes to the organization of peripheral myelinated axons. PLoS One. 2011;6(9):e25043
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory