Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Map3k12tm1.1Lewc
Name:	mitogen-activated protein kinase kinase kinase 12; targeted mutation 1.1, Joseph W Lewcock
MGI ID:	MGI:5294468
Synonyms:	DLK-
Gene:	Map3k12  Location: Chr15:102406079-102425311 bp, - strand  Genetic Position: Chr15, 57.63 cM, cytoband F3
Alliance:	Map3k12tm1.1Lewc page

Germline Transmission:	Earliest citation of germline transmission: J:176956
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre mediated excision removed exons 2 through 5 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:176956)

Generation of the Map3k12tm1.1Lewc allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k12 Mutation:	39 strains or lines available

Original:	J:176956 Ghosh AS, et al., DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J Cell Biol. 2011 Sep 5;194(5):751-64
All:	2 reference(s)