Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fstl1tm1.2Mvdh
Name:	follistatin-like 1; targeted mutation 1.2, Maurice JB van den Hoff
MGI ID:	MGI:5293374
Synonyms:	Fstl1-
Gene:	Fstl1  Location: Chr16:37597417-37656878 bp, + strand  Genetic Position: Chr16, 26.48 cM
Alliance:	Fstl1tm1.2Mvdh page

Germline Transmission:	Earliest citation of germline transmission: J:176532
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Homologous recombination was employed to insert an Frt-flanked neo cassette followed by an loxP site after exon 2 of Fstl1 and another loxP site before exon 2. Chimeric males were crossed to FVB females, and the offspring were crossed to Flpe deleters to remove the neo cassette, and then crossed to CMV-cre transgenic animals to delete exon 2. (J:176532)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

20 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fstl1 Mutation:	44 strains or lines available

Original:	J:176532 Sylva M, et al., The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PLoS One. 2011;6(8):e22616
All:	1 reference(s)