Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irag1tm2.1Jens
Name:	inositol 1,4,5-triphosphate receptor associated 1; targeted mutation 2.1, Jens Schlossmann
MGI ID:	MGI:5292572
Synonyms:	IRAGL1
Gene:	Irag1  Location: Chr7:110467473-110581668 bp, - strand  Genetic Position: Chr7, 57.9 cM
Alliance:	Irag1tm2.1Jens page

Germline Transmission:	Earliest citation of germline transmission: J:175887
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was flanked with a floxed neo cassette and an additional loxP site. Cre-mediated recombination removed the neo cassette and exon 3. The absence of protein expression was confirmed by western blot analysis on aorta or colon extracts. (J:175587)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irag1 Mutation:	50 strains or lines available

Original:	J:175887 Desch M, et al., IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation. Cardiovasc Res. 2010 Jun 1;86(3):496-505
All:	5 reference(s)