Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dcdc2atm1.2Jjlo
Name:	doublecortin domain containing 2a; targeted mutation 1.2, Joseph J LoTurco
MGI ID:	MGI:5288003
Synonyms:	Dcdc2del2
Gene:	Dcdc2a  Location: Chr13:25239987-25394689 bp, + strand  Genetic Position: Chr13, 10.89 cM
Alliance:	Dcdc2atm1.2Jjlo page

Germline Transmission:	Earliest citation of germline transmission: J:175635
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 2. Quantitative real time PCR showed that expression levels are about 10 fold lower in homozygous mice compared to wild-type mice. (J:175635)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dcdc2a Mutation:	49 strains or lines available

Original:	J:175635 Wang Y, et al., Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin. Neuroscience. 2011 Sep 8;190:398-408
All:	5 reference(s)