Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lmx1atm1.1Tpe
Name:	LIM homeobox transcription factor 1 alpha; targeted mutation 1.1, Thomas Perlmann
MGI ID:	MGI:5287979
Synonyms:	Lmx1a-
Gene:	Lmx1a  Location: Chr1:167516806-167676310 bp, + strand  Genetic Position: Chr1, 75.08 cM
Alliance:	Lmx1atm1.1Tpe page

Germline Transmission:	Earliest citation of germline transmission: J:175535
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1and a floxed neo cassette was inserted 288 bp downstream of exon 2 via homologous recombination. Cre mediated recombination deleted exons 1and 2, intron 1 and part of intron 2. Immunohistochemical analysis confirmed the absence of wild-type protein expression in the ventral midbrain of homozygous embryos at E11.5. (J:175535)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmx1a Mutation:	20 strains or lines available

Original:	J:175535 Deng Q, et al., Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development. 2011 Aug;138(16):3399-408
All:	1 reference(s)