Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chrna4tm1.2Tmcg
Name:	cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1.2, Tresa M McGranahan
MGI ID:	MGI:5285619
Synonyms:	alpha4 -
Gene:	Chrna4  Location: Chr2:180664104-180685339 bp, - strand  Genetic Position: Chr2, 103.54 cM
Alliance:	Chrna4tm1.2Tmcg page

Germline Transmission:	Earliest citation of germline transmission: J:174505
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed exon 5 and the neo cassette. In situ hybridization confirmed the absence of transcript expression in brain samples. (J:174505)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrna4 Mutation:	42 strains or lines available

Original:	J:174505 McGranahan TM, et al., alpha4beta2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. J Neurosci. 2011 Jul 27;31(30):10891-902
All:	1 reference(s)