Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tdgtm1.1Abc
Name:	thymine DNA glycosylase; targeted mutation 1.1, Alfonso Bellacosa
MGI ID:	MGI:5285105
Gene:	Tdg  Location: Chr10:82465662-82486633 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Tdgtm1.1Abc page

Germline Transmission:	Earliest citation of germline transmission: J:174772
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked neo cassette with a loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exons 3 through 7. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:174772)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

List all tumor models in MMHCdb carrying Tdgtm1.1Abc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tdg Mutation:	23 strains or lines available

Original:	J:174772 Cortellino S, et al., Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell. 2011 Jul 8;146(1):67-79
All:	2 reference(s)