Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pappa2tm1Lex
Name:	pappalysin 2; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:5142320
Gene:	Pappa2  Location: Chr1:158539297-158788019 bp, - strand  Genetic Position: Chr1, 68.49 cM
Alliance:	Pappa2tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:174887
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment including exons 4 and 5 was replaced with a beta galactosidase neomycin fusion marker and a pgk-puro marker via homologous recombination. PCR analysis confirmed the absence of expression in multiple tissues from homozygous mice. (J:174887)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pappa2 Mutation:	87 strains or lines available

Original:	J:174887 Conover CA, et al., Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice. Endocrinology. 2011 Jul;152(7):2837-44
All:	1 reference(s)