About   Help   FAQ
Cav1tm1.1Aia
Targeted Allele Detail
Summary
Symbol: Cav1tm1.1Aia
Name: caveolin 1, caveolae protein; targeted mutation 1.1, Alexander I Agoulnik
MGI ID: MGI:5141474
Gene: Cav1  Location: Chr6:17306387-17341323 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2
Alliance: Cav1tm1.1Aia page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174719
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Immunohistochemistry confirmed the absence of protein expression in the uterus. (J:174719)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:  29 strains or lines available
References
Original:  J:174719 Li Z, et al., Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2. Endocrinology. 2011 Jun;152(6):2474-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory