Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hax1tm1.1Gach
Name:	HCLS1 associated X-1; targeted mutation 1.1, Gernot Achatz
MGI ID:	MGI:5056144
Gene:	Hax1  Location: Chr3:89902753-89906023 bp, - strand  Genetic Position: Chr3, 39.19 cM, cytoband F2
Alliance:	Hax1tm1.1Gach page

Germline Transmission:	Earliest citation of germline transmission: J:174159
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neomycin resistance cassette was inserted in intron 1 and a third loxP site was placed in intron 3. Transient transfection of properly targeted ES cells with a cre expressing vector results in excision of both the selection cassette and exons 2 and 3. No protein was detectable in bone marrow-derived cells or other tissues. (J:174159)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hax1 Mutation:	36 strains or lines available

Original:	J:174159 Peckl-Schmid D, et al., HAX1 deficiency: impact on lymphopoiesis and B-cell development. Eur J Immunol. 2010 Nov;40(11):3161-72
All:	1 reference(s)