Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tph2tm1.1Zfc
Name:	tryptophan hydroxylase 2; targeted mutation 1.1, Zhou-Feng Chen
MGI ID:	MGI:5007662
Gene:	Tph2  Location: Chr10:114914546-115020927 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance:	Tph2tm1.1Zfc page

Germline Transmission:	Earliest citation of germline transmission: J:170988
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5 and the selection cassette. (J:170988)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

73 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tph2 Mutation:	41 strains or lines available

Original:	J:170988 Liu Y, et al., Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature. 2011 Apr 7;472(7341):95-9
All:	10 reference(s)