Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Dhrs4tm1Lex
Name:	dehydrogenase/reductase 4; targeted mutation 1, Lexicon Pharmaceuticals
MGI ID:	MGI:5007107
Gene:	Dhrs4  Location: Chr14:55716215-55727797 bp, + strand  Genetic Position: Chr14, 28.19 cM
Alliance:	Dhrs4tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:171883
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The Dhrs4 gene consists of 5 exons, with the start codon located in exon 1 (NCBI accession NM_030686.1). Exons 1 and 2 were targeted by homologous recombination. Disruption of the target gene was confirmed by Southern hybridization analysis. (J:171883)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dhrs4 Mutation:	22 strains or lines available

Original:	J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All:	2 reference(s)