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Osr1tm2.1Jian
Targeted Allele Detail
Summary
Symbol: Osr1tm2.1Jian
Name: odd-skipped related transcription factor 1; targeted mutation 2.2, Rulang Jiang
MGI ID: MGI:5003112
Synonyms: Osr1deltaE2
Gene: Osr1  Location: Chr12:9624442-9631500 bp, + strand  Genetic Position: Chr12, 4.05 cM
Alliance: Osr1tm2.1Jian page
Dilated epicardium, hemorrhaging, and edema in Osr1tm2.1Jian/Osr1tm2.1Jian embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171478
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Cre-mediated recombination removed exon 2. Homozygous mice recapitulate the phenotype of null mice. (J:171478)
Generation of the Osr1tm2Jian, Osr1tm2.1Jian, and Osr1tm2.2Jian alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Osr1 Mutation:  16 strains or lines available
References
Original:  J:171478 Gao Y, et al., The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol. 2011 Apr 1;352(1):83-91
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory