Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grin1tm2.1Stl
Name:	glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 2.1, Susumu Tonegawa
MGI ID:	MGI:4950588
Synonyms:	Grin1Delta, Grin1null
Gene:	Grin1  Location: Chr2:25181193-25209199 bp, - strand  Genetic Position: Chr2, 17.14 cM
Alliance:	Grin1tm2.1Stl page

Germline Transmission:	Earliest citation of germline transmission: J:170830
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Grin1tm2Stl homozygous mice were bred to the deleter strain Meox2tm1(cre)Sor/+ to generate mice with global deletion of one copy of Grin1. (J:37457, J:170830)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grin1 Mutation:	64 strains or lines available

Original:	J:170830 Beutler LR, et al., Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4206-11
All:	7 reference(s)