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Lrrk2tm1.1Mjff
Targeted Allele Detail
Summary
Symbol: Lrrk2tm1.1Mjff
Name: leucine-rich repeat kinase 2; targeted mutation 1.1, The Michael J Fox Foundation
MGI ID: MGI:4943782
Synonyms: Lrrk2tm1.1Youy
Gene: Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance: Lrrk2tm1.1Mjff page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170000
Parent Cell Line:  ART B6-3, B6-3 (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 39-40 of the leucine-rich repeat kinase 2 (Lrrk2) gene with a loxP-flanked neomycin resistance (neo) cassette. Correctly targeted ES cells were transiently transfected with a Cre recombinase expression plasmid to delete the neo cassette. Correctly targeted ES cells were injected into blastocysts and resulting chimeric mice were bred to C57BL/6NTac mice. (J:170000)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:  156 strains or lines available
References
Original:  J:170000 Ouyang Y, Generation of a new Lrrk2 knockout allele. MGI Direct Data Submission. 2011;
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory