Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Qpcttm1.2Tbay
Name:	glutaminyl-peptide cyclotransferase (glutaminyl cyclase); targeted mutation 1.2, Thomas A Bayer
MGI ID:	MGI:4941596
Gene:	Qpct  Location: Chr17:79359335-79397807 bp, + strand  Genetic Position: Chr17, 49.83 cM, cytoband E3
Alliance:	Qpcttm1.2Tbay page

Germline Transmission:	Earliest citation of germline transmission: J:169481
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: LoxP sites were inserted into intron 3 and 5. Flp-mediated recombination removed the FRT-flanked neo cassette, and cre-mediated recombination removed exons 4 and 5. The absence of transcript expression was confirmed by RT-PCR. (J:169481)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Qpct Mutation:	8 strains or lines available

Original:	J:169481 Jawhar S, et al., Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice. J Biol Chem. 2011 Feb 11;286(6):4454-60
All:	4 reference(s)