Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vti1atm1Gfvm
Name:	vesicle transport through interaction with t-SNAREs 1A; targeted mutation 1, Gabriele Fischer von Mollard
MGI ID:	MGI:4940029
Gene:	Vti1a  Location: Chr19:55304727-55615741 bp, + strand  Genetic Position: Chr19, 51.35 cM, cytoband D2
Alliance:	Vti1atm1Gfvm page

Germline Transmission:	Earliest citation of germline transmission: J:169107
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neo cassette was inserted into exon 6, which encodes part of the SNARE motif. The absence of protein expression was confirmed by western blot analysis on E18.5 brain extracts. (J:169107)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

33 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vti1a Mutation:	48 strains or lines available

Original:	J:169107 Kunwar AJ, et al., Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2575-80
All:	5 reference(s)