Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rhebl1tm1.1Pfw
Name:	Ras homolog enriched in brain like 1; targeted mutation 1.1, Paul Worley
MGI ID:	MGI:4939475
Synonyms:	Rheb2-
Gene:	Rhebl1  Location: Chr15:98775659-98779424 bp, - strand  Genetic Position: Chr15, 54.99 cM, cytoband F2
Alliance:	Rhebl1tm1.1Pfw page

Germline Transmission:	Earliest citation of germline transmission: J:168571
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted into the 5'UTR region of exon 1 and an FRT flanked PGK-neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed part of exon 1, all of exon 2 and the neo cassette. (J:168571)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhebl1 Mutation:	19 strains or lines available

Original:	J:168571 Zou J, et al., Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011 Jan 18;20(1):97-108
All:	1 reference(s)