Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Daglatm1.1Kano
Name:	diacylglycerol lipase, alpha; targeted mutation 1.1, Masanobu Kano
MGI ID:	MGI:4881474
Synonyms:	alpha-KO, DGLalpha KO
Gene:	Dagla  Location: Chr19:10222629-10282241 bp, - strand  Genetic Position: Chr19, 6.55 cM
Alliance:	Daglatm1.1Kano page

Germline Transmission:	Earliest citation of germline transmission: J:167891
Parent Cell Line:	RENKA (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3, and an additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette and exons 3 and 4. The absence of protein expression was confirmed by immunohistochemistry on the brain. (J:167891)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dagla Mutation:	60 strains or lines available

Original:	J:167891 Tanimura A, et al., The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron. 2010 Feb 11;65(3):320-7
All:	9 reference(s)