Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkag1tm1.2Mfor
Name:	protein kinase, AMP-activated, gamma 1 non-catalytic subunit; targeted mutation 1.2, Marc Foretz
MGI ID:	MGI:4880680
Gene:	Prkag1  Location: Chr15:98710678-98729354 bp, - strand  Genetic Position: Chr15, 54.73 cM
Alliance:	Prkag1tm1.2Mfor page

Germline Transmission:	Earliest citation of germline transmission: J:167779
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked hygro cassette with a 3' loxP site was inserted upstream of exon 3, and an additional loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the hygro cassette and cre-mediated recombination removed exons 3 through 7 floxed. The absence of protein expression was confirmed in liver, muscle, white adipose tissue, brown adipose tissue, kidney, and spleen extracts. (J:167779)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkag1 Mutation:	29 strains or lines available

Original:	J:167779 Foretz M, et al., The AMPKgamma1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia. FASEB J. 2011 Jan;25(1):337-47
All:	3 reference(s)