Prkab2tm1.1Grst
Targeted Allele Detail
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| Symbol: |
Prkab2tm1.1Grst |
| Name: |
protein kinase, AMP-activated, beta 2 non-catalytic subunit; targeted mutation 1.1, Gregory R Steinberg |
| MGI ID: |
MGI:4868754 |
| Gene: |
Prkab2 Location: Chr3:97565527-97581128 bp, + strand Genetic Position: Chr3, 42.25 cM
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| Alliance: |
Prkab2tm1.1Grst page
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Smaller Type IIA and IIB muscle fibers in Prkab2tm1.1Grst/Prkab2tm1.1Grst extensor digitorium longus muscles
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:167339
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| Parent Cell Line: |
Bruce 4 (ES Cell)
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| Strain of Origin: |
B6.Cg-Thy1a
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP was inserted upstream of exon 2, and a floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed exons 2 through 4 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on heart and red vastus extracts.
(J:167339)
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Generation of the Prkab2tm1Grst and Prkab2tm1.1Grst alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Prkab2 Mutation: |
29 strains or lines available
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| Original: |
J:167339 Steinberg GR, et al., Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem. 2010 Nov 26;285(48):37198-209 |
| All: |
7 reference(s) |
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Analysis Tools
