Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	B3gnt5tm1Big
Name:	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; targeted mutation 1, Darell D Bigner
MGI ID:	MGI:4867401
Gene:	B3gnt5  Location: Chr16:19578958-19591503 bp, + strand  Genetic Position: Chr16, 12.23 cM, cytoband B1
Alliance:	B3gnt5tm1Big page

Germline Transmission:	Earliest citation of germline transmission: J:166763
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of intron 3 and the coding region of exon 4 were replaced with a neo cassette via homologous recombination. RT-PCR confirmed the absence of expression in multiple tissues in fetal and adult mice. (J:166763)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any B3gnt5 Mutation:	24 strains or lines available

Original:	J:166763 Kuan CT, et al., Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis. BMC Dev Biol. 2010;10:114
All:	1 reference(s)